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Supplementation with alpha-tocopherol and ascorbic acid to non-alcoholic fatty liver disease’s statin therapy in men

Evaluation of the benefit of supplementation with alpha-tocopherol and ascorbic acid to non-alcoholic fatty liver disease’s statin therapy in men - Randomized Controlled Trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20180425001
Enrollment
Unknown
Registered
2018-04-25
Start date
2017-09-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non&#45

Interventions

20 mg atorvastatin daily,20 mg atorvastatin daily + 400 IU of vitamin E and 1000 mg of vitamin C daily,Healthy controls.
Active Comparator Drug,Experimental Drug,No Intervention No treatment
Atorvastatin,Atorvastatin+vitC+vit E,Control

Sponsors

Ss. Cyril and Methodius University in Skopje
Lead Sponsor
Faculty of Natural Sciences and mathematics &#45
Collaborator
Skopje
Collaborator

Eligibility

Sex/Gender
Male
Age
35 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients were required to have hepatorenal contrast and liver brightness according to the scoring system by doi:10.1111/j.1572-0241.2007.01526.x

Exclusion criteria

Exclusion criteria: Patients were excluded if they had any other chronic liver disease, malignancy or inflammatory disease.

Design outcomes

Primary

MeasureTime frame
Normalization of the activity of antioxidant enzymes At the end of the intervention Enzyme activity—

Secondary

MeasureTime frame
Normalization of the serum lipid profile At the end of the intervention Concentration in serum,Normalization of the aminotransferase levels At the end of the intervention Activity in serum,Normalization of CRP levels At the end of the intervention Concentration in serum—

Countries

Republic of Macedonia

Contacts

Public ContactNikola Hadzi-Petrushev

Faculty of Natural Sciencens and Mathematics - Skopje

nikola@pmf.ukim.mk+38978274003

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026