Melasma on both sides of the face chlorasma melasma mask of pregnancy HIFU
Conditions
Interventions
One side of the face was randomly assigned to be treated by HIFU. Treatment was performed with 1.5 mm-
transducer,
fluence 0.2 J/cm2 for consecutive 3 sessions including at baseline,
at the 4th week,
and 8th week.,Another side of the face was randomly assigned to receive no treatment for comparison purpose.
Experimental Device,No Intervention No treatment
high intensity focused ultrasound (HIFU),Placebo
Sponsors
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine Ramathibodi Hospital
Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: -bilateral mixed type melasma on face -able to comply with treatment regulations -able to attend every appointment assigned
Exclusion criteria
Exclusion criteria: -allergic to topical hydroquinone -being pregnant or lactating woman -currently/previously having skin cancers -having a history of keloid/hypertrophic scars -having autoimmune diseases -active acne vulgaris on face -having/had oral contraceptive pills or hormone replacement therapy within 1 year -used topical whitening within 3 months -underwent laser treatment within 6 months -had filler injection on experimental sites within 1 year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relative lightness index Baseline and every 4 weeks after treatment (a total of 6 visits) At each visit, luminance scores were obtained from lesions and were subtracted by normal skin | — |
Secondary
| Measure | Time frame |
|---|---|
| modified melasma area and severity index (mMASI) Baseline and every 4 weeks after treatment (a total of 6 visits) Assessed by dermatologists,Improvement score 4th visit (16 weeks after treatment) 5-point scale was rated by patients,Satisfaction score 4th visit (16 weeks after treatment) visual analogue scale was rated by patients | — |
Contacts
Public ContactWimolsiri Iamsumang
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine Ramathibodi Hospital
Outcome results
None listed