Effect of Short-term Bisoprolol on Perioperative Myocardial Injury in Patient Undergoing Non-cardiac Surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20180329005

Enrollment

Unknown

Registered

2018-03-29

Start date

2012-11-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The patient who undergo abdominal aortic surgery The patient who undergo infrainguinal arterial reconstruction surgery The patient who undergo non&#45

Interventions

Concor 2.5 mg. Active ingredient is bisoprolol fumarate.,Placebo comparator is the tablet of Maize starch

Active Comparator Drug,Placebo Comparator Drug

Bisoprolol,Placebo

Eligibility

Sex/Gender

All

Age

45 Years to No maximum

Inclusion criteria

Inclusion criteria: The study will include all patients, aged more than 45 year, who are postmenopausal or are using a reliable means of contraception and undergo major elective abdominal aortic or infrainguinal arterial reconstruction surgery or non-cardiac thoracic surgery under general anesthesia at Maharaj Nakorn Chiang Mai hospital.

Exclusion criteria

Exclusion criteria: â€¢ Patients will be excluded if they meet any of the following criteria: 1. Already taking beta-blockers 2. Giving beta-blockers will be dangerous (e.g., known intolerance to beta-blockers) 3. Receiving current treatment for asthma/COPD 4. Presence of bradycardia (heart rate < 60 bpm) or hypotension (systolic blood pressure <100 mm Hg) 5. Plan to use a beta â€“ blocker preoperatively or during the first 30 postoperative days for other reason 6. Concurrent use of verapamil, diltiazem or amiodarone 7. Urgent / emergency vascular surgery within 24 hr 8. Have had CABG with complete revascularization in 5 years & no evidence of ischemia since surgery 9. Active cardiac condition 10. Not give informed consent 11. Pregnancy

Design outcomes

Primary

Measure	Time frame
Incidence of perioperative myocardial injury Day 1, Day 2 and day 3 Troponin T level	—

Secondary

Measure	Time frame
Incidence of cardiovascular event 30 day cardiovascular death, nonfatal MI and nonfatal stroke until 30 days after surgery	—

Countries

Thailand

Contacts

Public ContactWanwarang Wongcharoen

Faculty of Medicine, Chiang Mai University

bwanwarang@yahoo.com053 936 716

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Effect of Short&#45;term Bisoprolol on Perioperative Myocardial Injury in Patient Undergoing Non&#45;cardiac Surgery