medical refractory epilepsy Kinetic modelling Compartmental model Biodistribution Technetium 99m ECD Serial SPECT Localization Seizure onset zone Epileptogenic zone Epilepsy
Conditions
Interventions
-
Medically refractory epilepsy plan surgical treatment
,-
No history of neurologic or psychiatric disorder
Diagnostic,Diagnostic
Medically refractory epilepsy,normal volunteer
Sponsors
Ratchadapisek Research Funds
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Target population -Aged 18-60 years -Medically refractory epilepsy -Not pregnancy or breastfeeding Control population -Aged 18-60 years -No history of neurologic or psychiatric disorder -Not pregnancy or breastfeeding
Exclusion criteria
Exclusion criteria: Target population -History of cerebrovascular disease -History of psychiatric disorder -Develop seizure while scanning -Unable to undergo serial brain SPECT -Unable to define region of interest of the SOZ by visual assessment, SISCOM, eZIS, extracranial EEG and intracranial EEG -Low quality image which are not suitable for data analysis Control population -Unable to undergo serial brain SPECT -Low quality image which are not suitable for data analysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| seizure onset zone 1 day after SPECT scan serial brain SPECT | — |
Secondary
| Measure | Time frame |
|---|---|
| kinetic parameter 1 day after SPECT scan serial brain SPECT | — |
Contacts
Public ContactCHANAN SUKPRAKUN
King Chulalongkorn Memorial Hospital
Outcome results
None listed