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An efficacy and safety comparing topical 5% azelaic acid versus 2% minoxidil solution in treatment of androgenetic alopecia in female: a randomized controlled trial

An efficacy and safety comparing topical 5% azelaic acid versus 2% minoxidil solution in treatment of androgenetic alopecia in female: a randomized controlled trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20180319001
Enrollment
60
Registered
2018-03-19
Start date
2018-03-14
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

female androgenetic alopecia

Interventions

Patients with female androgenetic alopecia were randomized to receive 5% azelaic acid. Patients apply 1 cc of 5% azelaic acid on the scalp twice a day for 24 weeks.,Patients with female androgenetic a
Experimental Drug,Experimental Drug
topical 5% azelaic acid ,topical 2% minoxidil solution

Sponsors

Institutional review and signing
Lead Sponsor
Institutional review and signing&#44
Collaborator
Faculty of Medicine Siriraj Hospital&#44
Collaborator
Mahidol University
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: - Female patients, older than 18 years of age, who were diagnosed with androgenetic alopecia. - Patients have never been treated for at least 6 months prior to the study. - Patients agree to participate in the research project and can complete the treatment throughout the period.

Exclusion criteria

Exclusion criteria: - People with congestive heart disease, such as anemia, diabetes, chronic alcoholism, previous gastrointestinal surgery, short bowel syndrome, Crohn's disease, digestive disorder, hypo / hyperthyroidism, autoimmune disease - Patients with other skin lesions in the treatment area, such as psoriasis, fungal infection on the scalp - Patients with impaired mental status, including trichotillomania

Design outcomes

Primary

MeasureTime frame
Comparative efficacy of 5% azelaic acid and 2% minoxidil solution in female androgenetic alopecia 6 months To evaluate the difference of hair density, hair shaft diameter

Secondary

MeasureTime frame
To study the safety of 5% azelaic acid and 2% minoxidil solution 6 months history and physical examination every visits after applying the study's drug

Countries

thailand

Contacts

Public ContactKanchalit Thanomkitti

Department of dermatology, Siriraj Hospital, Mahidol university

kanchalitt@gmail.com080-440-6014

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026