Basic epigenetic events (global methylation and histone acetylation) in aggressive variants of thyroid cancer including anaplastic,
Conditions
Interventions
archived FFPE sections of surgically removed ATC,
MTC and PDTC samples (1. Department of Pathology,
Chulalongkorn University,
2. Department of Pathology,
Khonkaen University,
3. Hi-
Tech Lab Co. Ltd.)
patients’ records retrieved from the database /case histories. These cancers were diagnosed base on criteria mentioned in WHO Classification of Tumours of Endocrine Organs (4th edition) published in
Basic Science
ATC,
MTC and PDTC samples
Sponsors
Faculty of Medicine, Chulalongkorn University
Faculty of Medicine,
Chulalongkorn University
Eligibility
Sex/Gender
All
Age
0 Years to 99 Years
Inclusion criteria
Inclusion criteria: Morphologically verified thyroid cancers, including ATC, MTC and PDTC
Exclusion criteria
Exclusion criteria: Cases with missing clinical data, samples of inadequate size (less than 5 mm) and low quality which are not suitable for IHC analysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| basic epigenetic events (global methylation and histone acetylation) Cohort of 2004-2015 years Immunohistochemistry (automated scoring) | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparing methylation and acetylation score Cohort of 2004-2015 years Immunohistochemistry (automated scoring) | — |
Countries
Thailand
Contacts
Public ContactThiyaphat Laohawetwanit
Department of Pathology, Faculty of Medicine, Chulalongkorn University
Outcome results
None listed