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Effect of consumption of probiotic containing Saccharomyces boulardii to extended-spectrum beta-lactamases (ESBL)-producing Escherichia coli in carrier persons: A randomized controlled trial

Effect of consumption of probiotic containing Saccharomyces boulardii to extended-spectrum beta-lactamases (ESBL)-producing Escherichia coli in carrier persons: A randomized controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20180313002
Enrollment
Unknown
Registered
2018-03-13
Start date
2018-01-05
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ESBL E. coli carriers

Interventions

A probiotic capsule&#44
contain Saccharomyces boulardii 282.5 mg each. FDA number 1C391/49 ,Made to looked&#44
smelled&#44
tested like Bioflor capsule. Contain only maltodextrin. No medical effect.
Bioflor 250 (CAPSULES),Placebo

Sponsors

Department of Microbiology, Phramongkutklao College of Medicine
Lead Sponsor
Department of Pharmacology&#44
Collaborator
Phramongkutklao College of Medicine
Collaborator

Eligibility

Sex/Gender
All
Age
19 Years to No maximum

Inclusion criteria

Inclusion criteria: - living in Phrapleng community, Sa Keaw Province, Thailand - age over 18 years old - Stool culture positive for ESBL E. coli - consent to participate in the research

Exclusion criteria

Exclusion criteria: - Immunocompromised host eg. AIDs, immunosuppressant users etc. - consummation of active microbiota food eg. curd, yogurt etc. at the time of intervention carry (3 weeks) - taking antibiotics that effect ESBL bacteria; Carbapenems, Beta-lactamase inhibitor and Aminoglycosides at the time of intervention carry (3 weeks)

Design outcomes

Primary

MeasureTime frame
prevalence of ESBL E. coli carriers after intervention in both groups of participants before and after intervention Screening test by stool culture on selective ESBL agar, confirmatory test by MALDI-TOF and combine

Secondary

MeasureTime frame
N/A N/A N/A

Countries

Thailand

Contacts

Public ContactPiyanete Kesakomol

Phramongkutklao college of medicine

k.piyanate@gmail.com023547765

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026