Septic shock Thiamine
Conditions
Interventions
Thiamine 200 mg + 5%DW 50 mL iv drip in 30 min for 7 days,5%DW 50ml iv drip in 30 min for 7 day
Experimental Drug,Placebo Comparator Other
Thiamine group,Placebo group
Sponsors
Hospital fund
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age over 18 years 2. On vasopressor duration between 1-24 hours 3. Inform consent 4. Suspected infection
Exclusion criteria
Exclusion criteria: 1.recieve thiamine > 100 mg last 24 hours 2. Thiamine allergy or anaphylaxis 3. Cancer that survival rate < 50% at 6 months 4. Who was agnosed cardiac beriberi, peripheral beriberi, korsakoff syndrome, re-feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vasopressor free day for 7 days 24 hours Number of day free vasopressor | — |
Secondary
| Measure | Time frame |
|---|---|
| Lactate reduction 24 h 24 hr Variable data,Vasopressor dependency reduction 24 h 24 h Variable data,SOFA score change for 7 days 7 days Variable data,Vasopressor dependency index 7 days Variable data,28 day mortality 28 day Variable data | — |
Countries
Thailand
Contacts
Public ContactSuttasinee Petsakul
Ramathibodi hospital
Outcome results
None listed