lung cancer natural killer cell activity Lymphocytes subset postoperative pulmonary function test pain score opioids consumption dexmedetomidine natural killer cell natural killer cell activity immunity lung cancer surgery anesthesia
Conditions
Interventions
dexmedetomidine 0.5 mcg/kg iv drip in 20 min then continuous infusion at 0.5 mcg/kg/h until 30 min before end of operation,Normal saline infusion at same rate of study drug
Experimental Drug,Placebo Comparator No treatment
Sponsors
Chulalongkorn university
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patient undergoing surgery for lung cancer - age more than 18 year-old - ASA physical I-III - BMI < 30 kg/m2
Exclusion criteria
Exclusion criteria: - allergy to any drug in the study - emergency surgery - cardiac arrhythmia , bradycardia (HR < 50/min) - severe liver disease - Chronic kidney disease stage 4-5 - previous immunosuppressive drug within 1 year - patient with immune disorder - previous chemotherapy or radiation within 3 months - previous history of thoracic surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Natural Killer cell activity before induction of anesthesia, 3 hours and 48 hours after anesthesia cytotoxicity assay | — |
Secondary
| Measure | Time frame |
|---|---|
| pulmonary function test at 1 hour postoperative Portable spirometry ,lymphocyte subpopulation phenotype before induction of anesthesia, 3 hours and 48 hours after anesthesia flow cytometry,postoperative pain 0-48 hours postoperative numeric rating scale score, fentanyl consumption | — |
Countries
Thailand
Contacts
Public ContactAnantachote Vimuktanandana
faculty of medicine, Chulalongkorn university
Outcome results
None listed