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The efficacy and safety of 1% lidocaine hydrochloride as diluent in Benzathine penicillin G injection in comparison to sterile water as diluent to reduce injection pain among Thai patients with syphilis: A randomized control trial

The efficacy and safety of 1% lidocaine hydrochloride as diluent in Benzathine penicillin G injection in comparison to sterile water as diluent to reduce injection pain among Thai patients with syphilis: A randomized control trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20180308001
Enrollment
40
Registered
2018-03-08
Start date
2018-04-28
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

syphilis

Interventions

1% lidocaine hydrochloride as diluent in Benzathine penicillin G injection,sterile water as diluent in Benzathine penicillin G injection
Experimental Drug,Active Comparator Drug

Sponsors

Siriraj hospital
Lead Sponsor
Siriraj hospital
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Male or female aged at least 18 years old 2. Diagnosed with Syphilis of any stage 3. Has been Prescribed with Benzathine penicillin G injection 1.2 million unit on each buttock

Exclusion criteria

Exclusion criteria: 1. Allergic to penicillin or any other drugs that can cross react to cause allergy or anaphylaxis 2. Allergic to any anesthetic drugs 3. pregnancy 4. on any pain medication in the past 72 hours

Design outcomes

Primary

MeasureTime frame
Pain Score 24 hours quantitative measurement of 0-10—

Secondary

MeasureTime frame
side effects of 1% lidocaine hydrochloride as diluent in Benzathine penicillin G injection 24 hours rash anaphylaxis inflammation and infection—

Countries

Thailand

Contacts

Public ContactSukhum Jiamton

SIRIRAJ

sukhum.jiamton@gmail.com0819172781

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026