Proportion of low energy hip fracture patients who had normal serum vitamin D level after three months of treatment in different dose of vitamin D2 supplement.
Conditions
Interventions
Vitamin D2 supplement dose 20,
000 IU/week,Vitamin D2 supplement dose 60,
Experimental Drug,Experimental Drug
dose group,high-
dose group
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: All patient who admitted to Siriraj Hospital , Mahidol University, Bangkok, Thailand, between July,10 2016 – June, 15 2017. They were invited to participate if they were aged 50 years or over and presenting with a low energy hip fracture, peritrochanteric or neck of femur fracture
Exclusion criteria
Exclusion criteria: patients who suffered from associated pathological fracture from malignancy or other metabolic bone disease such as paget’s disease, Hyperparathroidism; hypercalcemia (>10.2 mg/dL)[27]; history of disease that high risk for altered serum calcium level such as tumor, granulomatous disease; significant renal impairment (GFR ≤ 30 ml/min); liver disease (AST or ALT level >2 times the upper limit of the normal range); undergoing supplement with oral vitamin more than 400 IU daily; undergoing treatment with drug that may altered serum 25(OH)D level such as phenytoin, phenobarbital; history of malabsorbtion disease such as radiation enteritis, inflammatory bowel disease, short bowel syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of low energy hip fracture patients who had normal vitamin D level 12 weeks serum 25(OH)D >=30 ng/mL,Proportion of low energy hip fracture patients who had normal vitamin D level 12 weeks serum 25(OH)D >=30 ng/mL | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum calcium level of low energy hip fracture patients 12 weeks Change in serum calcium level, ng/mL | — |
Countries
Thailand
Contacts
Public ContactSuchat Phusunti
Siriraj Hospital
Outcome results
None listed