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Effect of Vitamin C, thiamine and hydrocortisone on mortality in septic shock, a randomized placebo-controlled trial

Effect of Vitamin C, thiamine and hydrocortisone on mortality in septic shock, a randomized placebo-controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20180302002
Enrollment
62
Registered
2018-03-02
Start date
2018-02-26
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subject with septic shock who Medical admitted.

Interventions

treatment group : vitamin C 1.5 gm + NSS 100 ml IV infusion 30 min q 6 hr combination with Hydrocortisone 200 mg+ NSS 250 ml IV infusion in 24 hr combination with Thiamine 200 mg + NSS 100 ml IV inf
Experimental Drug,Placebo Comparator Other
treatment group,Control

Sponsors

no
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: o Septic shock o Age>= 18 yr o Admitted at Medical ICU

Exclusion criteria

Exclusion criteria: o pregnancy o G6PD deficiency o No CPR o allergy of Vit.C or Thiamine o Terminally ill patients eg. malignancy, end-stage heart diseases

Design outcomes

Primary

MeasureTime frame
28 day mortality rate 28 day rate of death—

Secondary

MeasureTime frame
ICU length of stay ICU period duration og ICU stay—

Countries

Thailand

Contacts

Public ContactJuthamas Inchai

Faculty of Medicine, Chiang Mai University

juinchai@gmail.com053936396

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026