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Effects of dietary Centella asiatica extract on cognition and oxidative stress markers in elderly with mild cognitive impairment

Effect of dietary Centella asiatica extract on cognition and oxidative stress markers: A Double-blinded Randomized Placebo-Controlled Trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20180228001
Enrollment
Unknown
Registered
2018-02-28
Start date
2015-10-01
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild Cognitive Impairment (MCI) is commonly being used to refer a stage of cognitive impairment prior to attaining clinical dementia in Alzheimer disease. The plant Centella asiatica (L) Urban is used dementia&#44

Interventions

1 g Centella asiatica crude extract capsules,Placebo&#45
controlled
Experimental Dietary Supplement,Placebo Comparator No treatment
Centella asiatica crude extract capsules,Placebo

Sponsors

Kasetsart University Research and Development Institute
Lead Sponsor
Kasetsart University Research and Development Institute
Collaborator

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: Men and women were aged 65 yrs and above. They obtained a Mini-Mental State Examination (MMSE) score of ≤23.

Exclusion criteria

Exclusion criteria: Presentation cardiovascular and/or cerebrovascular disease, uncontrolled hypertension and diabetes, liver and kidney function impairment, or the presence of other medical conditions with significant psychiatric or neurologic consequence.

Design outcomes

Primary

MeasureTime frame
Cognitive function at 8 weeks after end of the intervention Mini-Mental State Examination (MMSE), reaction time—

Secondary

MeasureTime frame
Oxidatives stress at 8 weeks after end of the intervention Acetylcholinesterase Competitive Enzyme Immunoassay Kit,Vitamin E at 8 weeks after end of the intervention high performance liquid chromatography (HPLC)—

Countries

Thailand

Contacts

Public ContactJatuporn Phoemsapthawee

Faculty of Sports Science, Kasetsart University

jatuporn.w@ku.th66(0)870595940

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026