Effect of vitamin C with bioflavonoids supplementation on immune cell function after low-intensity exercise in patients with poor glycemic control type II diabetes mellitus

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20180227001

Enrollment

Unknown

Registered

2018-02-27

Start date

2014-07-25

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetic patients especially in poor glycemic control (HbA1c â‰¥ 8.5% or â‰¥ 69 mmol/mol) patient with type 2 diabetes

Interventions

Anti&#45

inflammation and anti&#45

oxidant properties,To perform a cycling for 20 min at low&#45

intensity exercise

Experimental Dietary Supplement,Experimental Procedure/Surgery

Vitamin C with bioflavonoids supplementation,low&#45

Eligibility

Sex/Gender

All

Age

45 Years to 60 Years

Inclusion criteria

Inclusion criteria: Poor glycemic control T2D patients (45-60 years old) obtained from Khon Kaen hospital and Srinagarind hospital, Khon Kaen province in Thailand after providing written informed consent. There are eight participants for determination of the lymphocyte subpopulations and four from eight participants for IL-17 production. All participants were diagnosed T2D for at least a year before enrollment and present HbA1c levels â‰¥ 8.5% (HbA1c levels â‰¥ 69 mmol/mol). Individuals with T2D were medicated with oral hypoglycemic medicine (mostly metformin) and not participated for at least 6 months prior in any regular exercise program.

Exclusion criteria

Exclusion criteria: Exclusion criteria were liver, kidney, cardiovascular disease, chronic infections (HIV, TB, Hepatitis), changed types and doses of anti-hypertensive, hypoglycemic or lipid-lowering drugs prescription, regularly supplemented with antioxidant, blood pressure higher than 140/90 mmHg, abnormal resting EKG, neuromuscular disorders and orthopedic problems

Design outcomes

Primary

Measure	Time frame
The effect of oral CB supplementation on PMN function after low-intensity exercise 10/07/2017 Flow cytometry,N/A N/A N/A	—

Secondary

Measure	Time frame
Effect of CB supplementation and exercise on cell subpopulation and IL17 production 10/07/2017 Flow cytometry	—

Countries

Thailand

Contacts

Public ContactNisa Chuangchot

Biomedical science, Graduate School, Khon Kaen University

nisachuang@gmail.com+66 95669 0924

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026

Effect of vitamin C with bioflavonoids supplementation on immune cell function after low&#45;intensity exercise in patients with poor glycemic control type II diabetes mellitus