sexual function in postmenopausal women conjugated estrogens tablet vaginal administration sexual function postmenopausal women sexual dysfunction Vaginal pH Vaginal atrophy symptoms Vaginal maturation index Number of lactobacilli,
Conditions
Interventions
vaginal administration of oral conjugated estrogens tablet (Estromon 0.625 mg) 1 tablet once daily for 3 weeks then 1 tablet twice weekly for 9 weeks,vaginal administration of oral conjugated estrogen
Experimental Drug,Placebo Comparator Drug
vaginal administration of conjugated estrogens tablet,vaginal administration of conjugated estrogens tablet placebo
Sponsors
Ratchadapiseksompot Endowment Fund
Faculty of medicine,
Chulalongkorn University
Eligibility
Sex/Gender
Female
Age
45 Years to 70 Years
Inclusion criteria
Inclusion criteria: Being amenorrhea for at least 1 year (according to diagnostic definition of menopause by WHO) Consent was given Vaginal pH >5 Atleast on vaginal atrophic symptoms in moderate intensity TFSFI score not over 26.5 Well communicable in Thai History of engagement in sexual intercourse at least 2 times a month
Exclusion criteria
Exclusion criteria: Pathologic cause of menopause : primary ovarian insufficiency, underwent oophorectomy, radiation/chemotherapy induced menopause History of receiving hormone or other therapy affecting vaginal mucosa History of abnormal vaginal discharge or bleeding not yet evaluated nor treated History of vaginal or cervical surgery within 3 months prior to enrollment Personal or family history of estrogen related malignancy Having contraindication for hormonal use History of sex steroid hormone / steroid use within 2 months prior to enrollment History of psychiatric condition Having active sexual partner with history of sexual dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sexual function in postmenopausal women at 12 weeks after starting of the intervention FSFI score | — |
Secondary
| Measure | Time frame |
|---|---|
| Vaginal atrophy symptoms (The most bothersome symptom) at 12 weeks after starting of the intervention Vaginal atrophy symptoms (The most bothersome symptom),Vaginal pH at 12 weeks after starting of the intervention pH paper,The number of lactobacilli at 12 weeks after starting of the intervention Gram staining and count under light microscope with magnification,vaginal maturation index at 12 weeks after starting of the intervention Staining and count under light microscope with magnification,Normal Flora Index at 12 weeks after starting of the intervention Gram staining and count under light microscope with magnification | — |
Countries
Thailand
Contacts
Public ContactThanapob Bumphenkiatikul
Unaffiliated
Outcome results
None listed