A randomized control trial of the effect of restricted protein diet to delay renal replacement therapy in septic patients with acute renal failure

A randomized control trial of the effect of restricted protein diet to delay renal replacement therapy in septic shock patients with acute renal failure in Thammasat university hospital

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20180217001

Enrollment

Registered

2018-02-17

Start date

2017-11-27

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

&#45

Interventions

protein 0.9&#45

1 gm/kg/day,protein 1.2&#45

1.5 gm/kg/day

Active Comparator Dietary Supplement,Placebo Comparator Dietary Supplement

low protein ,normal protein

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - acute kidney injury stage 2 within 48 hour - septic shock require inotrophic drug - on tube feeding or parenteral nutrition - no nutritional support contraindication

Exclusion criteria

Exclusion criteria: - reject current disease management - on renal replacement therapy in past or within 24 hour after acute kidney injury diagnosis - acute kidney injury from renal artery, glomerulonephritis, interstitial nephritis, vasculitis, post renal obstruction, hemolytic uremic syndrome, thrombotic thrombocytopenia purpura, hepatorenal syndrome, cardiorenal syndrome - Very high catabolism (burn) - protein-losing enteropathy

Design outcomes

Primary

Measure	Time frame
timing from AKI to dialysis timing from AKI to dialysis logrank test	—

Secondary

Measure	Time frame
30 day mortality rate 30 days persent,infection complication rate 30 days persent	—

Countries

Thailand

Contacts

Public ContactSanit Wichansawakun

Faculty of medicine Thammasat university

Wichansawakun@gmail.com0816919606

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026