Patients with knee osteoarthritis
Conditions
Interventions
oral Tramadol KCL 50mg,oral Naproxen 250mg
Active Comparator Drug,Active Comparator Drug
Tramadol,Naproxen
Sponsors
Khon Kaen hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Eligible patients were 20 years of age or older with a diagnosis of unilateral primary or secondary osteoarthritis of the knee defined by the American College of Rheumatology criteria.
Exclusion criteria
Exclusion criteria: Patients were excluded if they had used of analgesic e.g., acetaminophen, topical NSAIDs, and topical methyl salicylate or anti-inflamma drugs including NSAIDs and corticosteroids within one week before recruitment, diagnosed with rheumatoid arthritis, fibromyalgia, ankylosing spondylitis, active gout, pseudogout, or other inflammatory disorder, inflammatory or post-infectious arthritis, previous major knee trauma (knee fracture, knee subluxation/dislocation, neurovascular injury), previous arthroscopic treatment or total knee replacement, previous drug allergy or intolerance for opioid or NSAIDs, history of ASCVD (stroke, coronary heart disease) or high risk for ASCVD, history of drug or alcohol abuse, history of peptic ulcer disease, from patient or recorded in the patient card, hepatic or renal impairment (AST or ALT above normal range, GFR below 30 ml/min/1.73 m2), diagnosis of severe persistent asthma or COPD (uncontrolled symptom with exacerbate everyday), platelet <100,000 mm3, pregnancy or breast feeding (by LMP).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain dimension of Western Ontario and Mcmaster Universities Osteoarthritis Index (WOMAC) 2 weeks between-group mean difference from baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| stiffness, and physical-function dimension of WOMAC scores as well as its total score, serum liver e 2 weeks between-group mean difference from baseline | — |
Countries
Thailand
Contacts
Public ContactTeerasak Ouncharoen
Khon Kaen Hospital
Outcome results
None listed