Adult inpatients who were admitted in medical general wards with the diagnosis mild to moderate acute hypoxia. high flow nasal oxygen,
Conditions
Interventions
Standard Oxygen supplementation via nasal cannula.,HFNO system consists of nasal cannula,
heated inspiratory circuit,
humidifier,
oxygen blender and flow meter. Gas from air-
oxygen blender is humidified and heated before given to patient.
Active Comparator Device,Active Comparator Device
standard oxygen therapy ,High-
Sponsors
no
Eligibility
Sex/Gender
All
Age
18 Years to 0 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: all the following 1. Mild to moderate acute hypoxemic respiratory failure(table) 2. Admitted at general medical wards 3. Age >18 years old Definition of mild to moderate hypoxemic respiratory failure • Respiratory rate >25 breaths/min and/or increased work of breathing, evidenced by clinical signs (dyspnea, use of accessory muscles of respiration, diaphoresis) AND • Requiring >4 L/min O2 via nasal cannula or requiring O2 therapy equivalent to FiO2 >0.4 to keep PaO2 >60 mmHg or SpO2 >90% for >1 hour
Exclusion criteria
Exclusion criteria: 1. PaCO2 >45 mmHg 2. Post-extubation respiratory failure (respiratory failure within 48 hr after extubation) 3. Life-threatening ARF requiring immediate IMV 4. Shock 5. Contraindications to NIV 6. A do-not-intubate order 7. Patients refused to participate the study 8. Intra-abdominal hypertension 9. Pulmonary tuberculosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of required NIV or IMV within 48 hours after randomization within 48 hours after randomization Number of subject who need NIV or IMV initiation within 48 hours after randomization | — |
Secondary
| Measure | Time frame |
|---|---|
| 30-day mortality 30 day Number of subject died at 30 day after randomization | — |
Contacts
Public ContactChalerm Liwsrisakun
Chiang Mai University
Outcome results
None listed