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The effect of inhalation anesthesia with hyperventilation and total intravenous anesthesia (TIVA) on ICP control in pediatrics with craniosynostosis surgery: A randomized clinical trial

The effect of inhalation anesthesia with hyperventilation and total intravenous anesthesia (TIVA) on ICP control in pediatrics with craniosynostosis surgery: A randomized clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20180129002
Enrollment
Unknown
Registered
2018-01-29
Start date
2016-05-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

In this prospective clinical trial study&#44

Interventions

In hyperventilation group (A) patients received isoflurane for maintenance of anesthesia and hyperventilation (Paco2=25&#45
30 mmHg) established during surgery. ,The total intravenous anesthesia (TIVA) group (B) received propofol infusion for anesthesia maintenance and Paco2 was maintained 35 mmHg.
Experimental Drug,Experimental Drug
inhalation anesthesia with hyperventilation ,total intravenous anesthesia (TIVA)

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Months to 2 Years

Inclusion criteria

Inclusion criteria: pediatric patients ASA class І -ІІ, age 6 months-2 years old undergoing multiple sutures cranioplasty. Patients with concurrent cardiac, renal, hematologic or pulmonary disease and BMI> 30 were excluded

Exclusion criteria

Exclusion criteria: N/A

Design outcomes

Primary

MeasureTime frame
Intra cranial pressure . During surgery qualitative scale—

Secondary

MeasureTime frame
Hemodynamic (mean arterial pressure and heart rate) changes During surgery standard monitoring (Blood pressure (BP), Pulse rate (PR), Electrocardiography (ECG), end tidal carb—

Countries

iran

Contacts

Public ContactAfsaneh Sadeghi

Anesthesiologist, Anesthesiology Research Center (ARC), Shahid Beheshti University of Medical Scienc

are20935@yahoo.com+9802333452740

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026