Cardiac disease Delirium Prevention Cardiac Quetiapine
Conditions
Interventions
Oral Quetiapine 12.5 mg at bedtime on preoperative day and postoperative day 0,
1 (3 days) ,Oral placebo at bedtime on preoperative day and postoperative day 0,
1 (3 days)
Experimental Drug,Placebo Comparator Drug
Sponsors
Ramathibodi hospital
Eligibility
Sex/Gender
All
Age
55 Years to No maximum
Inclusion criteria
Inclusion criteria: Age 55 yr or more Patients underwent cardiac surgery with cardiopulmonary bypass Written informed consent
Exclusion criteria
Exclusion criteria: Emergency surgery Patients with psychiatric disease or delirium Patients received cholinesterase inhibitors, levodopa and antipsychotic Patients with prolong QT Allergy to quetiapine Patients who were admitted in ICU or were intubated prior study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium at postoperative Day 0,1,2,3 CAM-ICU score | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of delirium at postoperative Day 0,1,2,3 days,Length of ICU stay at postoperative Day 0,1,2,3 days,Length of hospital stay at postoperative Day 0,1,2,3 days,Complication at postoperative Day 0,1,2,3 number count | — |
Countries
Thailand
Contacts
Public ContactNarut Ruananukun
Ramathibodi Hospital
Outcome results
None listed