To investigate cardiopulmonary responses to exercise in Thai patients with idiopathic pulmonary arterial hypertension (IPAH),
Conditions
Interventions
Experimental protocol
Physical examinations
Physical examinations including measurement of vital signs (heart rate,
respiratory rate,
and body temperature),
assessment of lung sound,
and screening for jaundice,
paleness and edema will be conducted by a physician.
WHO functional class
The WHO functional class will be assessed by a cardiologist following criteria by PH guidelines Table 3 (Galiè et al.,
2015).
N-
terminal prohormone of brain natriuretic peptide
Measurement of NT-
proBNP will be performed using the Elecsys proBNP ELISA (Roche Diagnostics,
Mannheim,
Germany). NT-
proBNP is considered high when levels are ≥ 125 pg/ml (McMurray et al.,
2012).
Anthropometry
Height and weight will be measured in all subjects,
according to the WHO guidelines (World Health Organization,
2011). Subjects will wear light clothing and no shoes. Weight will be measured to the nearest tenth of a kilogram using a digital scale. Height will be measured standing with feet together and arms re
standing position,
respectively. WC and HC will be used to calculate waist to hip ratio W/H ratio based on the WHO guidelines (World Health Organization,
2011).
9.7.5 Echocardiogram
PH patients will undergo Doppler echocardiography. Estimated right ventricular systolic pressure (ERVSP) will be determined with the modified Bernoulli equation using the
measur
Sponsors
Research Affair Faculty of Medicine Khon Kaen University
my self
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age more than 20 years old 2. Subjects with diagnosis of RHC 3. Diagnosis of systemic sclerosis by rheumatologist according to systemic sclerosis guidelines (van den Hoogen et al., 2013) 4. Diagnosis of CTEPH according to the PH guidelines (Galiè et al., 2015) by cardiologist and hematologist
Exclusion criteria
Exclusion criteria: 1. Unwillingness or inability to perform the testing procedure 2. Subjects with a history of cardiovascular disease (i.e. coronary heart disease, chronic HF and myocardial infarction) within 3 months before test 3. Subjects with a history of systemic infections within 3 months before test 4. Subjects with symptoms of respiratory tract infection within 6 weeks prior to the study 5. Subjects with absolute contraindications of CPET 6. Subjects with type 2, 3, or 5 PH 7. SSc patients who cannot use treadmill due to conditions such as painful, ischemic ulcers, active myositis, extremity contracture, severe malnutrition, and polyneuropathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gas exchange promptly CPET parameters | — |
Secondary
| Measure | Time frame |
|---|---|
| NT-proBNP promptly Blood sample | — |
Countries
Thai
Contacts
Public ContactBurabha Pussadhamma
department of medicine faculty of medicine khon kaen university
Outcome results
None listed