The word stomatitis means inflammation of oral mucosa. Denture stomatitis (DS) thus indicates inflammation of oral mucosa under the denture. Lesions of DS are more frequently found in the upper jaw,
Conditions
Interventions
Alcohol free chitosan-
curcumin mouthwash based on PEG 400 and water as cosolvent,
containing 0.1% curcumin was prepared. Each time a 10 mL of freshly prepared chitosan-
curcumin mouthwash was given to patient for mouthwash for 30 sec three times a day at 8 am,
12 pm and 4 pm for two weeks.,Formulation with chitosan (0.5%) but without curcumin was used. 10 mL of chlorhexidine mouthwash solution was given each time for mouthwash for 30 sec three times a day a
12 pm and 4 pm for two weeks., 20% chlorhexidine stock solution was diluted to 0.2% to be used by patient. 10 mL of chlorhexidine mouthwash solution was given each time for mouthwash for 30 sec three
12 pm and 4 pm for two weeks.
0.1% Chitosan-
curcumin moutwash,0.1% Chitosan moutwash,0.2% Chlorhexidine mouthwah
Sponsors
Department of Clinical Pharmacy
Department of Stomatology
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. 20 years of age and older 2. Confirm of denture stomatitis by the oral medicine specialists 3. Able to use mouthwash correctly
Exclusion criteria
Exclusion criteria: 1. Patients with open mouth sores at study entry. 2. Patients with HIV infections, diabetes mellitus, or hyperthyroidism. 3. Patients using any other prophylactic mouthwashes within last month. 4. Patients who required use of any form of treatment/medicaments (e.g., antibiotics, analgesics, etc.) during the course of study. 5. Patients who had received any recent treatment with antifungal, antibacterial, chemotherapeutic and immunosuppressive agents within last month 6. Pregnant woman 7. Patients who are allergic to chitosan-curcumin mouthwash or chlorhexidine solution 8. Patients with mouth ulcers from other causes eg. trauma, aphthous ulcer at study entry
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete relief of erythematous lesions or reduction of diameter of erythematous lesion under dentur prior intervention, 2 weeks after inervention Site activity score from challacomb scale was used to evaluate and grade the lesions under denture,Reduction in number of colonies of Candida present in oral cavity of the patients. prior intervention, after intervention 2 week, Oral rinse method was used to collect C. albicans, culture for fungus and count for number | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in number of colonies of Candida present in oral cavity of the patients prior intervention, after intervention 2 week Oral swab and oral rinse method was used to collect C. albicans, culture for fungus and count for nu | — |
Countries
Thailand
Contacts
Public ContactKanokporn Pangsomboon
Department of Pharmaceutical Technology
Outcome results
None listed