Dypsnea in do-
Conditions
Interventions
92% for hypercapnic participants for 60 minutes. After that,
high flow oxygen is delivered by OptiflowTM cannula using an AirvoTM flow source (Fisher & Paykel Healthcare Ltd). The initial flow will be set at 35 L/min and can be increased up to 60 L/min. FiO2 wi
92% for hypercapnic participants and maintain there for 60 minutes.,High flow oxygen is delivered by OptiflowTM cannula using an AirvoTM flow source (Fisher & Paykel Healthcare Ltd). The initial flow
92% for hypercapnic participants and maintain there for 60 minutes. After that,
92% for hypercapnic participants for 60 minutes.
Experimental Procedure/Surgery,Experimental Procedure/Surgery
Plan A,Plan B
Sponsors
None
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age > 18 years old 2. Do-not-intubate status 3. Presented with respiratory distress meeting all of the following criteria a. Pulse oximetry < 90% when breathing at room air b. Dyspnea (modified Borg scale ≥ 4) c. Signs of respiratory distress e.g. accessory muscle use d. Respiratory rate ≥ 30 breaths/min 4. Competent status: Kelly score < 4
Exclusion criteria
Exclusion criteria: 1. Refusal of treatment 2. Agitation or non-cooperation 3. Adverse reactions or contraindication to opioids 4. Participants contraindicated for NHF such as excessive secretion, risk of aspiration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease in degree of dypsnea 15th, 30th, 60th, 75th, 90th, 120th minute Modified Borg scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Degree of dyspnea 15th, 30th, 60th, 75th, 90th, 120th minute Numeric rating scale,Total morphine use in 1-hour and 2- hour period milligram,Respiratory rate 15th, 30th, 60th, 75th, 90th, 120th minute Direct auscultation of respiratory cycle,SpO2 15th, 30th, 60th, 75th, 90th, 120th minute pulse oximetry,Heart rate and blood pressure 15th, 30th, 60th, 75th, 90th, 120th minute automatic blood pressure and heart rate monitor,Adverse event rate from equipment use within 2 hour of intervention Patient reported by themself,Hospital length of stay Until hospital discharge Hours, days,Mortality rate Until hospital discharge Discharge status | — |
Countries
Thai
Contacts
Public ContactOnlak Ruangsomboon
Department of emergency medicine, faculty of medicine siriraj hospital, mahidol university
Outcome results
None listed