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Asynchrony index and breathing patterns of acute exacerbation COPD patients assisted with noninvasive pressure support ventilation and neurally adjusted ventilatory assist

Comparison of Breathing Patterns and Patient Ventilator Asynchrony between Noninvasive Neurally Adjusted Ventilatory assist (NIV NAVA) and Pressure Support Ventilation (NIV PSV) in AECOPD: a Crossover Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20171016005
Enrollment
Unknown
Registered
2017-10-16
Start date
2015-01-01
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator asynchrony acute exacerbation COPD patients noninvasive pressure support ventilation(NIV&#45

Interventions

Set NAVA level to maintain pressure as the patients receive during NIV&#45
PS and set the same level of PEEP as PEEP that the patients receive during NIV&#45
PS and run in period,Set pressure support level to maintain tidal volume 6&#45
8 ml./Kg IBW and set the same level of PEEP as PEEP that the patients receive during NIV&#45
PS during run in period and NIV&#45
NAVA
Active Comparator Device,Active Comparator Device
NIV&#45
NAVA,NIV&#45

Sponsors

None listed

Eligibility

Sex/Gender
All
Age
40 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.stable AECOPD patients with impending or acute respiratory failure using NIV-PS 2.stable AECOPD patients with NIV-PS for weaning operational definition of stable AECOPD patients -patients with stable hemodynamics -no need to adjust ventilator setting for at least 2 hours -no need additional sedation -no need frequent bronchodilator: less than 2 nebules in 30 minutes -no need frequent suction: less than 2 times in 2 hours

Exclusion criteria

Exclusion criteria: 1.patients with phrenic nerve dysfunction 2.patients with diaphragmatic disorder 3.patients with impaired respiratory drive 4.patients who have contraindications of EAdi catheter insertion eg. gastroesophageal varices, gastroesophageal obstruction, recent surgery of esophagus or stomach, recent upper gastrointestinal bleeding 5.end of life care patients 6.pregnancy 7.patients with unfit mask problem 8.Claustrophobia

Design outcomes

Primary

MeasureTime frame
asynchrony index last 20 minutes during each study period percent,types of asynchrony last 20 minutes during each study period percent, frequency—

Secondary

MeasureTime frame
time delay or premature time last 20 minutes during each study period mean values of time (milliseconds),Tidal volume variability last 20 minutes during each study period COV of millilitres per kilograms of ideal body weight,respiratory rate variability last 20 minutes during each study period COV of rates per minute,EAdi Variability last 20 minutes during each study period COV of microvolts—

Countries

Thailand

Contacts

Public ContactNapplika Kongpolprom

Chulalongkorn University

napplika@yahoo.com0909617486

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026