Aphthous ulcer
Conditions
Interventions
Experimental Drug,Active Comparator Drug
Acemannan in orabase,Triamcinolone acetonide in orabase
Topical application of 0.5% acemannan in orabase on the ulcer 3 times a day,Topical application of 0.1% acemannan in orabase on the ulcer 3 times a day
Sponsors
Faculty of Dentistry, Naresuan University
Research Unit of Herbal Medicine and Natural Product for Dental Application,
Chulalongkorn Universit
Eligibility
Sex/Gender
All
Age
15 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Willing to participate and signed the informed-consent forms 2. Has 1-3 aphthous ulcers of < 48 hours duration on nonkeratinized oral mucosa 3. Ulcer size is 2–10 mm in diameter 4. Healthy (not having systemic disease)
Exclusion criteria
Exclusion criteria: 1. History of allergies to aloe vera, acemannan,or triamcinolone in orabase 2. Previously treatment with topical triamcinolone acetonide in this aphthous ulcer 3. Pregnancy and/or lactation 4. Having oral bacteria/fungal/viral infections 5. Having systemic disease process which involved with aphthous ulceration or impaired wound healing such as ulcerative colitis, Crohn’s disease, Behcet’s syndrome, or diabetes mellitus or anemia 6. Dental surgery within 2 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound size reduction 2, 5, and 7 days after applied treatment Measurement and calculate the remaining wound area | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain reduction 2, 5, and 7 days after applied treatment Visual Analog Scale (VAS) | — |
Contacts
Public ContactSuwimon Jettanacheawchankit
Deparment of Oral Biology, Faculty of Dentistry, Naresuan University
Outcome results
None listed