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Conditions
Interventions
Blood samples collections 20 ml at Day 0 (at first visit),Blood samples collections 20 ml at Day 0 (at first visit),Blood samples collections 20 ml at Day 0 (at first visit) and at Day 60 after placeb
Experimental No treatment,Experimental No treatment,Experimental Drug,Experimental Drug
Healthy control,Naive TN,CBZ-
treated TN patients with placebo,CBZ-
treated TN patients with CoQ10
Sponsors
Thailand Research Fund Grants
NSTDA Research Chair Grant from the National Science and Technology Development Agency Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: -Adult (≥ 18 years old) -Present with features of TN, based on current guidelines of the Headache Classification Committee of the International Headache Society (IHS)
Exclusion criteria
Exclusion criteria: -Patients with painful trigeminal neuropathy (e.g. due to the growth of organic lesions or tumors) -Acute infectious disease within the previous three weeks -Past or present neurological, psychiatric, metabolic, cardiovascular, muscular, or chronic inflammatory disease -Smoking habits or alcohol consumption of more than 40 g/day -Medical conditions that required treatment with glucocorticoids, analgesics, or antidepressant drugs -Pregnancy or current breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oxidative stress levels 24 h Reactive oxygen species (ROS) production in PBMCs by flow cytometry measurement | — |
Secondary
| Measure | Time frame |
|---|---|
| pro-inflammatory cytokines including TNF-α, IL-1β and IL-18 mRNA expression 24 h SYBR Green quantitative real-time PCR (qRT-PCR) | — |
Countries
Thailand
Contacts
Public ContactChutikorn Khuankaew
Cardiac Electrophysiology Research and Training Center
Outcome results
None listed