feeding intolerance mechanically ventilated patient prokinetic feeding intolerance mechanically ventilated patients erythromycin estolate gastric residual volume
Conditions
Interventions
Erythromycin estolate 250 mg (10 mL) every 6 hours combination with metoclopramide 10 mg IV every 6-
8 hours,Placebo suspension 10 mL every 6 hours combination with metoclopramide 10 mg IV every 6-
8 hours
Experimental Drug,Active Comparator Drug
Intervention group,Control group
Sponsors
Siam University
Faculty of Pharmaceutical Sciences,
Prince of Songkla University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Mechanically ventilated patients who had feeding intolerance, defined as GRV greater than or equal to 250 mL during receive either continuous or intermittent enteral feeding or GRV greater than or equal to 150 mL concomitant with vomiting, regurgitation or abdominal distension.
Exclusion criteria
Exclusion criteria: The patients who 1. received any prokinetics drugs within the past 24 hours 2. have a history of allergic to metoclopramide and/or macrolide antibiotics 3. required pharmacological treatment for seizure 4. have hemodynamically unstable or any cardiac arrhythmia or prolonged QTc > 480 msec. on a 12-lead ECG 5. was diagnosed with acute CNS infection 6. was diagnosed with acute severe brain injury from any causes 7. have hyperbilirubinemia 8. currently received carbamazepine, digoxin, warfarin, haloperidol or perphenazine 9. have undergone small bowel or large bowel surgery within 6 weeks before study 10. have a history of esophagectomy or partial/total gastrectomy at any time before study 11. was diagnosed with myasthenia gravis or pheochromocytoma 12. was suspected or confirmed bowel obstruction or perforation, 13. were expected to be extubated within 48 hours 14. Declined to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| % successful feeding at 48 hours 48 hours Total calories | — |
Secondary
| Measure | Time frame |
|---|---|
| % successful feeding day 1-7 actual total calories ,% administered/ targeted calorie requirement ratio day 1-7 gastric residual volume,Length of hospital stay (LOS) until discharge The number of hospitalization days,Hospital mortality rate until discharge mortality rate,incidence of pneumonia day 1-7 incidence of pneumonia,incidence of arrhythmia day1-7 incidence of pneumonia,incidence of diarrhea day1-7 incidence of diarrhea,Gastric Residual Volume (GRV) day 1-7 total mean GRV /day,Total calories day 1-7 total calories/day | — |
Countries
Thailand
Contacts
Public ContactTaniya Charoensareerat
Siam University
Outcome results
None listed