A prospective randomized control trial comparing the effect of Chloramphenicol ointment with Recombinant Human Epidermal Growth Factor on facial burn wound healing

A prospective randomized control trial comparing the effect of Chloramphenicol ointment with Recombinant Human Epidermal Growth Factor on secon degree facial burn wound healing

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20171004003

Enrollment

Registered

2017-10-04

Start date

2017-11-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Second degree burn wound Facial burn wound healing Recombinant Human Epidermal Growth Factor promote wound healing Burn Facial burn Burn wound healing Chloramphenicol ointment Recombinant Human Epidermal Growth Factor rhEGF

Interventions

Apply Recombinant Human Epidermal Growth Factor combine Chloramphenicol ointment ,Apply only Chloramphenicol ointment

Experimental Drug,Active Comparator Drug

Recombinant Human Epidermal Growth Factor group,Chloramphenicol ointment group

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: - Age 18-65 years old - Second degree facial burn wound area > 1 %BSA - Burn in 48 hours

Exclusion criteria

Exclusion criteria: - Immunocompromised host - Using steroids, chemotherapy, immunosuppressive drugs - Allergy to chloramphenicol, recombinant human epidermal growth factor or Isopropyl p-Hydroxybenzoate - Breast feeding or pregnancy

Design outcomes

Primary

Measure	Time frame
Complete healing day Evaluate every 2 days Area of granulation tissue that measure from eKare inSightâ„¢ 3D Wound	—

Secondary

Measure	Time frame
Effect of drug on wound pain Evaluate every 2 days after change wound dressing for 30 minutes Numeric pain score [0 to 10],Effect of drug on wound infection rate Evaluate every 2 days Fever, Wound appearance; erythema, swelling, pus discharge, fever, swab culture ; bacteria >10^5 CFU,Effect of drug on scar appearance 2,6 months after complete healing wound Vancouver scar scale,Side effects of drug Evaluate every 2 days after change wound dressing for 30 minutes Rash Irritation	—

Measure

Time frame

Effect of drug on wound pain Evaluate every 2 days after change wound dressing for 30 minutes Numeric pain score [0 to 10],Effect of drug on wound infection rate Evaluate every 2 days Fever, Wound appearance; erythema, swelling, pus discharge, fever, swab culture ; bacteria >10^5 CFU,Effect of drug on scar appearance 2,6 months after complete healing wound Vancouver scar scale,Side effects of drug Evaluate every 2 days after change wound dressing for 30 minutes Rash Irritation

—

Contacts

Public ContactNattakarn Changchit

Faculty of Medicine Siriraj Hospital , Mahidol University

bee20811@gmail.com0897929541

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026