Comparing end tidal sevoflurane in cirrhotic and non cirrhotic patients undergoing major hepatic resection using bispectral index

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20170929002

Enrollment

Registered

2017-09-29

Start date

2017-09-22

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sevoflurane Bispectralindex(BIS) Minimal alveolar concentration(MAC) Cirrhosis Hepatic resection Sevoflurane Bispectralindex(BIS) Minimal alveolar concentration(MAC) Cirrhosis Hepatic resection

Interventions

patient with cirrhotic liver who was scheduled for major hepatic resection with specialty hepatobiliary surgeon under combined general&#45

epidural anesthesia at King Chulalongkorn Memorial Hostipal,patient with non&#45

cirrhotic liver who was scheduled for major hepatic resection with specialty hepatobiliary surgeon under combined general&#45

epidural anesthesia at King Chulalongkorn Memorial Hostipal

Treatment,Treatment

Cirrhotic patient (Child A),Non&#45

cirrhotic patient

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: - patient who was scheduled for major hepatic resection(definition is anatomic hepatic resection more than 2 segments such as right hepatectomy, left hepatectomy , extended right hepatectomy , left lobectomy or extended left hepatectomy) with specialty hepatobiliary surgeon under combined general-epidural anesthesia at King Chulalongkorn Memorial Hostipal - age 20-65 years - American Society of Anesthesiology Physical Status (ASA) I-III ASA I : A normal healthy patient (Examples include Healthy, non-smoking, no or minimal alcohol use) ASA II : A patient with mild systemic disease Mild diseases only without substantive functional limitations (Examples include current smoker, social alcohol drinker, pregnancy, obesity (30 3 months) of MI, CVA, TIA, or CAD/stents.)

Exclusion criteria

Exclusion criteria: - refuse to participate this study - allergy to any drug in this study - serious diseases other than liver diseases, such as cardiovascular, respiratory or endocrine system conditions - contraindication for epidural catheter - taking chronic sedatives drug and opioid - alcoholics or drug abuse - psychaitic problems - a body mass index (BMI) â‰¥30 kg/m 2 - history of malignant hyperthermia

Design outcomes

Primary

Measure	Time frame
End tidal Sevoflurane Peri-operative peroid Percentage of end tidal Sevoflurane during peri-operative peroid	—

Secondary

Measure	Time frame
Volume of Sevoflurane consumption Peri-operative peroid milliliter of Sevoflurane consumption ,minimal alveolar concentration(MAC) Peri-operative peroid mean of minimal alveolar concentration(MAC)	—

Countries

Thailand

Contacts

Public Contactkirada Apisutimaitri

Faculty of medicine, Chulalongkorn University

kirada.api@gmail.com0814834274

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026