Expression of RANKL and OPG in saliva of type 1 diabetes mellitus patients in Thailand : a pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20170929001

Enrollment

Registered

2017-09-29

Start date

2017-10-02

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes mellitus type 1 patients have higher expression of RANKL and lower expression of OPG than healthy subjects. Diabetes mellitus type 1 patients have poorer periodontal conditions than healthy Expression of RANKL and OPG saliva type 1 diabetes mellitus patients Probing Depth Clinical attachment level bleeding on probing

Interventions

12% have been treated at Siriraj hospital. ,Control group is healthy patients who have age&#45

matched with Type 1 diabetes mellitus patients.

Basic Science,Basic Science

DMtype1,healthy

Type 1 diabetes mellitus patients which HbA1C 7&#45

Eligibility

Sex/Gender

All

Age

15 Years to 22 Years

Inclusion criteria

Inclusion criteria: Type 1 diabetes mellitus patients which HbA1C 7-12% have been treated at Siriraj hospital. Control group is healthy patients who have age-matched with Type 1 diabetes mellitus patients.

Exclusion criteria

Exclusion criteria: 1. Patient who have been periodontitis as a manifestation of systemic diseases such as Leukocyte adhesion deficiency, Ehler danlos syndrome, neutropenia, Down syndrome, Papillon-Lefvere syndrome, Chediak-Higashi syndrome, Histiocytosis syndrome, Glycogen storage disease, Infantile genetic agranulocytosis, Cohen syndrome, Hyphosphatasia, and leukemia 2. Immunodeficiency patients 3. Patients who cannot cooperate due to a lack of psychological or emotional maturity and/or mental, physical, or medical disability 4. Patients who take medication that effecting periodontium, bleeding disorder, and infection 5. Patients who recieved bisphosphonate 6. Patients who recieved orthodontics treatment 7. Smoking 8. Pregnant 9. Patients who have deciduous teeth 10. Patients who recieved periodontal treatment within 6 months

Design outcomes

Primary

Measure	Time frame
Expression of RANKL and OPG 0 second Real time Polymerase chain Reaction	—

Secondary

Measure	Time frame
probing depth 0 second millimetre/PCPUNC 15, Hu-Friedy,clinical attachment level 0 seconds millimetre/PCPUNC 15, Hu-Friedy,bleeding on probing 10 seconds observe bleeding on probing/PCPUNC 15, Hu-Friedy	—

Countries

Thailand

Contacts

Public ContactRachanin Chairatnathrongporn

Faculty of Dentistry, Mahidol University

som11370@hotmail.com66896883119

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026