A paired, randomized, double-blind, placebo-controlled trial of EMLA cream (eutectic mixture of local anesthetics) for primary localized cutaneous amyloidosis.

A paired, randomized, double-blind, placebo-controlled trial of EMLA cream (eutectic mixture of local anesthetics) for primary localized cutaneous amyloidosis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20170928005

Enrollment

Registered

2017-09-28

Start date

2017-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary localized cutaneous amyloidosis symmetry both legs primary localized cutaneous amyloidosis lichen amyloidosus EMLA topical anesthetic pruritus itch

Interventions

apply EMLA cream at one side of leg (leg A),apply placebo cream at one side of leg (leg B)

Experimental Drug,Placebo Comparator No treatment

EMLA cream,placebo (hydrophilic cream)

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 18-60 years old primary localized cutaneous amyloidosis at both legs symmetry

Exclusion criteria

Exclusion criteria: 1.previous laser within 3 months or use topical treatment within 1 month 2.other skin diseases 3.pregnancy or lactation 4.history of allergy to anesthesic agents or amide derivative 5.glucose-6-phosphatase defiency (G6PD) 6.using nitric oxide, sulfonamides, dapsone, metoclopramide, nitrofurantoin, beta-blockers drug 7.arrhythmia 8.immunodeficiency 9.psychiatric problem

Design outcomes

Primary

Measure	Time frame
pruritus 0 wk, 2 wk, 4 wk, 8 wk visual analog scale (VAS)	—

Secondary

Measure	Time frame
volume of elevated lesion 0 wk, 2 wk, 4 wk, 8 wk Antera 3D	—

Countries

Thailand

Contacts

Public ContactPravit Asawanonda

Faculty of Medicine, Chulalongkorn University

fibrosis@gmail.com022564253

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

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