Emergency surgery required rapid sequence induction of anesthesia Rapid sequence induction,
Conditions
Interventions
Standard dose 0.6 mg/kg for intubation,Use atracurium 0.75 mg/kg for intubation,Use atracurium 1 mg/kg for intubation
Active Comparator Drug,Active Comparator Drug,Active Comparator Drug
Controlled group,Atracurium 0.75,Atracurium 1
Sponsors
The Royal College of Anesthesiologists of Thailand (RCAT)
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective surgery, aged 20-65 years, and require general anesthesia 2. ASA physical status I-II
Exclusion criteria
Exclusion criteria: 1. Patients required emergency surgery 2. Unstable vital signs 3. History of difficult intubation or anticipated difficult intubation 4. Patients with history of neuromuscular disease 5. On anticonvulsant medication for more than 1 month 6. History of asthma or use bronchodilators 7. History of allergy to medications used in the study 8. Obesity, BMI >30
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intubating condition 1 minute after drug administration Likert scale for vocal cord and diaphragm movement during intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle blockade of atracurium TOF=0 Train-of-four (TOF),Muscle power recovery time TOF=2 Train-of-four (TOF),Hemodynamic 10 minutes after study drug administration BP, HR,adverse effect from study drug 10 minutes after study drug admistration rash, bronchospasm (high airway pressure) | — |
Contacts
Public ContactPornpan Chalermkitpanit
Chulalongkorn University
Outcome results
None listed