Outpatient who presents with acute pancreatitis. Outpatient,
Conditions
Interventions
Selected population who compatible with inclusion/exclusion criteria,
was resuscitated by Lactated Ringer'
s Solution followed study protocols and measure primary and secondary outcome after treatment 48 hours.,Selected population who compatible with inclusion/exclusion criteria,
was resuscitated by Acetatetated Ringer'
s Solution followed study protocols and measure primary and secondary outcome after treatment 48 hours.
Active Comparator Other,Active Comparator Other
Lactated Ringer'
s Solution group,Acetated Ringer'
s solution group
Sponsors
Gastroenterological association of Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients aged 18-80 years who were admit with diagnosis of acute pancreatitis. Diagnosis was comfirmed by the presence of 2 or more of the of the following criteria 1) Epigastric abdominal pain. 2) Elevation in serum amylase and/or lipase level greater than 3 times the upper limit of normal. 3) Confirmatory findings on cross-sectional imaging.
Exclusion criteria
Exclusion criteria: Known history of severe cardiovascular, respiratory, renal, hepatic, hematologic or immunologic disease. defined as 1. Aged 80 years or older. 2. Greater than New York Heart Association class II heart failure. 3. Active myocardial ischemia. 4. Cardiovascular intervention within previous 60 days. 5. History of cirrhosis. 6. Chronic kidney disease with creatinine clearance < 40 ml/min. 7. Chronic obstructive pulmonary disease with requirement for home oxygen. 8. Patients with a history of metastasis malignancy. 9. Patients with a history of autoimmune disease include autoimmune pancreatitis.. 10. Chronic infectious disease including HIV and tuberculosis. 11. Patients with infection including cholescystitis and cholangitis. 12. Patients with bowel ischemia and bowel perforation. 13. Patients with hypercalcemia. 14. Sepsis (presence of suspected or confirmed infection in setting of SIRS) 15. Rhabdomyolysis. 16. Post-intervention pancreatitis. 17. Severe pancreatitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SIRs (systemic inflamatory response) ratio at 48 hours after treatment 48 hours Comparison SIRs reduction at 48 hours after treatment in acute pancreatitis patient between Lactated | — |
Secondary
| Measure | Time frame |
|---|---|
| Response of inflammatory marker in acute pancreatitis patient. 48 hours Comparison inflamatory marker reduction ratio after treatment both groups | — |
Countries
Thailand
Contacts
Public ContactKantapat Volrapimol
Phramongkutklao Hospital
Outcome results
None listed