Moderate-to-severe thyroid eye disease patients Moderate-to-severe thyroid eye disease patients Inactive
Conditions
Interventions
Active Comparator Dietary Supplement,Placebo Comparator Dietary Supplement
Selenium group,Placebo group
Selenium supplementaion 200 mcg/capsule,PLacebo capsule
Sponsors
The Ratchadapiseksompotch Fund, Faculty of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.The patients who have been categorized into moderate-to-severe thyroid eye disease group according to EUGOGO recommendation. 2. Age above 18 years old 3. The patients with normal thyroid hormone level (FT4, FT3) for at least 6 months 4. The patients who presented with thyroid eye symptoms of less than 18 months.
Exclusion criteria
Exclusion criteria: 1. The patients who have history of allergic reaction to selenium 2. The patients who previously took or who are currently taking selenium supplement. 3. The patients who are pregnant or breast-feeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical activity score in moderate-to-severe thyroid eye disease patients 6 months Clinical activity score changes | — |
Secondary
| Measure | Time frame |
|---|---|
| GO-QOL questionnaire score, overall eye examination, serum selenium levels 6 months GO-QOL questionnaire score, overall eye examination, and serum selenium levels changes | — |
Countries
Thailand
Contacts
Public ContactPanida Potita
Department of ophthalmology, Chulalongkorn hospital
Outcome results
None listed