Acute Respiratory Distress Syndrome Recovering Phase Recovering ARDS PEEP Decrement Lung volume,
Conditions
Interventions
protocol based group,
which use lung volume change to guide decremental PEEP,physician based group,
which decremental PEEP by physician judgement
Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery
Protocol based :,Physician based
Sponsors
Ratchadapiseksompotch Fund, Faculty of medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. ARDS according to BERLIN definition 2010 and Recovering phase 2. admit in medical icu 3. on PEEP ≥ 3 cmH2O 4. on FiO2 ≤ 0.6 to keep SpO2 ≥ 90% 5. PaO2/FiO2 ≥ 150 mmHg 6. no increase FiO2 or PEEP to keep SpO2 ≥ 90% at lease 24 hours 7. SBP ≥ 90 mmHg and no increase vasopressor at least 6 hours
Exclusion criteria
Exclusion criteria: 1. age < 18 years 2. pneumothorax 3. lung bleb 4. auto PEEP 5. pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| lung collapse 30 minutes and 2 hours after PEEP decreament 2 cmH2O arterial blood gas and peripheral pulse oxymetry | — |
Secondary
| Measure | Time frame |
|---|---|
| Lung volume 30 minutes and 2 hours after PEEP decreament 2 cmH2O End expiratory lung volume | — |
Countries
Thailand
Contacts
Public ContactNapplika Kongponphrom
King Chulalongkorn Memorial Hospital
Outcome results
None listed