Preemptive gabapentin 600 mg for pain reduction after gynecologic surgery compare with placebo -
Conditions
Interventions
Gabapentin 600 mg orally 1 hour before surgery,Multivitamin in the same color of gabapentin orally 1 hour before surgery
Experimental Drug,Placebo Comparator Drug
Gabapentin,Multivitamin
Sponsors
none
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) body mass index below or equal 35 kg/m2 3) American Society of Anesthesiologists physical status (ASA) classification class I-II 4) Appointment to explore laparotomy for gynecologic surgery include total abdominal hysterectomy(TAH) with or without oophorectomy, salpingectomy, omentectomy, or lymphadenectomy 5) General anesthesia 6) Understand and can use visual analogue scale (VAS) 7) Understand and can use patient controlled analgesia (PCA)
Exclusion criteria
Exclusion criteria: 1) Allery to gabapentin or opioid 2) underlying disease of epilepsy, psychiatric disease, or chronic pain 3) Use addictive substance or analgesic within 48 hours before surgery 4) Ovarian or fallopian tube cancer 5) Expect for long operation than 4 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-operative pain score 2,4,8,12,24 hours after gynecologic surgery Visual analogue scale (VAS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Total morphine use(mg) 24 hours after operation 24 hours after operation Patient controlled analgesia (PCA) with morphine (mg),Side effect of morphine or gabapentin use(nausea,vomiting,dizziness,headache,fatigue,pruritis,etc) Within 24 hours after gynecologic surgery Observation and questionaire | — |
Countries
Thailand
Contacts
Public ContactPiyaphon Paktra
Phramongkutklao hospital
Outcome results
None listed