pulmonary tuberculosis patients pulmonary tuberculosis,
Conditions
Interventions
use high dose rifampicin 20 mg/kg/day in pulmonary tuberculosis patients . treatment course 6 months.,use standard dose rifampicin 10 mg/kg/day in pulmonary tuberculosis patients . treatment course 6
high dose rifampicin 20mg/kg/day,stardard dose rifampicin 10mg/kg/day
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Sputum AFB>= 1+ or sputum culture positive 2.X-pert gene no gene mutation
Exclusion criteria
Exclusion criteria: 1.Culture TB found rifampicin resistance 2.Previous treatment found drug resistance or high risk for drug resistant 3.History of relapse TB in past 2 years 4.CNS tuberculosis 5.military TB , pericardial TB,pleural TB 6.HIV patient with CD4 < 500 7.Age below 18 years or more than 80 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| increase rate and shorten time of sputum conversion 2 months after start treatment sputum culture | — |
Secondary
| Measure | Time frame |
|---|---|
| cure rate 6 months after start treatment sputum culture ,relapse rate 15 months after start treatment sputum culture ,poor outcome in 6 months course of treatment blood test | — |
Countries
thailand
Contacts
Public Contactnataphon wuthithepbuncha
Department of Medicine,Faculty of Medicine, King chulalongkorn Memorial hospital
Outcome results
None listed