postoperative delirium Risperidone postoperative delirium vascular patients
Conditions
Interventions
risperidone 1 mg sublingual is given within 1 hour after the operation,listerine strip sublingual is given within 1 hour after the operation
risperidone 1 mg sublingual,listerine strip sublingual
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
์N/A
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients are equal or older than 60 years old. 2. Vascular patient that have plan to operate (aorta, carotid and peripheral) who get anesthesia more than 2 hours. 3. Elective case
Exclusion criteria
Exclusion criteria: 1. Patients have cognitive impairment before surgery who get less than 24 score of Thai Mental State Examination (TMSE) 2. Patients who regularly drink alcoholic beverages and drink within the 14 days before surgery. 3. Pre-operative patients who have positive delirium when test with Confusion Assessment Method for Intensive Care Unit (CAM-ICU) 4. Patients with creatinine clearance < 30 ml/min 5. Patients with hepatic impairment with Child Pugh score greater than 10 6. Patients with history of risperidone allergy or history of neuroleptic malignant syndrome 7. Emergency case
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of postoperative delirium 7 days DSM V | — |
Secondary
| Measure | Time frame |
|---|---|
| length of hospital stay 30 days days,length of ICU stay 30 days days | — |
Countries
Thailand
Contacts
Public ContactOrawan Pongraweewan
Siriraj Hospital
Outcome results
None listed