A Randomized Comparison Between 2, 5 and 8 mg of Perineural Dexamethasone for Ultrasound-Guided Infraclavicular Block

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20170720001

Enrollment

360

Registered

2017-07-20

Start date

2017-07-22

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Regional anesthesia Infraclavicular brachial plexus block Anesthesia Analgesia

Interventions

The single&#45

injection perivascular infraclavicular block will be performed using 35 mL of lidocaine 1.0%&#45

bupivacaine 0.25% with epinephrine 5 mcg/mL and 2 mg of dexamethasone.,The single&#45

bupivacaine 0.25% with epinephrine 5 mcg/mL and 5 mg of dexamethasone.,The single&#45

bupivacaine 0.25% with epinephrine 5 mcg/mL and 8 mg of dexamethasone.

Active Comparator Drug,Active Comparator Drug,Active Comparator Drug

2 mg of perineural dexamethasone,5 mg of perineural dexamethasone,8 mg of perineural dexamethasone

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: - Patients undergoing upper extremity surgery (elbow and below). - American Society of Anesthesiologists classification 1 to 3 - Body mass index between 18 and 35 kg/m2

Exclusion criteria

Exclusion criteria: - pre existing neuropathy or coagulopathy - renal failure or hepatic failure - allergy to local anesthetics - pregnancy - prior surgery in the area of the infraclavicular fossa - chronic pain syndromes requiring opioid intake at home

Design outcomes

Primary

Measure	Time frame
Duration of motor blockade within 24 hours after the end of the procedure Record time from the end of local anesthetic injection and return of movement of hand and fingers	—

Secondary

Measure	Time frame
Duration of sensory blockade within 24 hours after the end of the procedure Record time from the end of local anesthetic injection and return of sensation of hand and fingers,Duration of analgesia within 24 hours after the end of the procedure Record the time from the end of local anesthetic injection and appearance of pain at surgical site,Success rate for surgical anesthesia within 2 hours after the end of the procedure Record the ability to proceed with surgery without the need for general anesthesia and rescue blocks,Complications within 60 minutes after the end of the procedure Record incidences of intravascular injection, systemic toxic, hematoma,Onset time within 30 minutes after the end of the procedure Record the time required to reach a minimal score of 14 out of 16 points,Performance time within 20 minutes after starting the procedure Record the time from applying ultrasound probe on skin to the end of local anesthetic drug injection,Number of needle passes during the procedure Record number of needle passes used to reach the target,Procedural pain at the end of the procedure Record pain during the procedure using visual analog scale from 0 to 10,Success rate of the procedure at 30 minutes after the end of the procedure Record the proportion of blocks with a minimal composition score of 14 out of 16 points	—

Measure

Time frame

Duration of sensory blockade within 24 hours after the end of the procedure Record time from the end of local anesthetic injection and return of sensation of hand and fingers,Duration of analgesia within 24 hours after the end of the procedure Record the time from the end of local anesthetic injection and appearance of pain at surgical site,Success rate for surgical anesthesia within 2 hours after the end of the procedure Record the ability to proceed with surgery without the need for general anesthesia and rescue blocks,Complications within 60 minutes after the end of the procedure Record incidences of intravascular injection, systemic toxic, hematoma,Onset time within 30 minutes after the end of the procedure Record the time required to reach a minimal score of 14 out of 16 points,Performance time within 20 minutes after starting the procedure Record the time from applying ultrasound probe on skin to the end of local anesthetic drug injection,Number of needle passes during the procedure Record number of needle passes used to reach the target,Procedural pain at the end of the procedure Record pain during the procedure using visual analog scale from 0 to 10,Success rate of the procedure at 30 minutes after the end of the procedure Record the proportion of blocks with a minimal composition score of 14 out of 16 points

—

Countries

Canada

Contacts

Public ContactVanlapa Arnuntasupakul

Mahidol University

vanlapaa@gmail.com6622011523

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

A Randomized Comparison Between 2&#44; 5 and 8 mg of Perineural Dexamethasone for Ultrasound&#45;Guided Infraclavicular Block