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Premedication with dexmedetomidine for prevention of hyperdynamic response after electroconvulsive therapy: a cross-over, randomized controlled trial

Dexmedetomidine for prevention of hyperdynamic responses to electroconvulsive therapy

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20170715003
Enrollment
24
Registered
2017-07-15
Start date
2017-07-21
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with psychiatric disease who undergo electroconvulsive therapy Dexmedetomidine, Electroconvulsive therapy

Interventions

Patient will be injected dexmedetomidine 0.5 mcg/kg before electroconvulsive therapy,Patient will be injected dexmedetomidine 1 mcg/kg before electroconvulsive therapy,Patient will be injected normal
dexmedetomidine 0.5 mcg/kg,dexmedetomidine 1 mcg/kg,Normal saline

Sponsors

Department of Anesthesiology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patients who need electroconvulsive therapy 2. Age 18-70 years old 3. ASA PHYSICAL STATUS 1-3

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Hepatic impairment 3. Patients who use beta blocker or narcotic drugs during electroconvulsive therapy 4. Patients who have contraindicated to dexmedetomidine

Design outcomes

Primary

MeasureTime frame
Blood pressure after electroconvulsive therapy 0,2.5,5,7.5,10,15,20,25,30 minute after electroconvulsive therapy non invasive blood pressure cuff,heart rate after electroconvulsive therapy 0,2.5,5,7.5,10,15,20,25,30 minute after electroconvulsive therapy Electrocardiogram

Secondary

MeasureTime frame
Post electroconvulsive agitation immediately after electroconvulsive therapy Agitation score,asystole duration immediately after electroconvulsive therapy second, Electrocardiogram,seizure duration immediately after electroconvulsive therapy second,seizure threshould immediately after electroconvulsive therapy Joules

Countries

Thailand

Contacts

Public ContactAtchaporn Laopuangsak

Faculty of Medicine Ramathibodi Hospital, Mahidol University

fai_bewitch@hotmail.com0873183869

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026