Patient sedation Hemodynamic changes Children Sedation Magnetic resonance imaging(MRI) Thiopental Dexmedetomidine Propofol
Conditions
Interventions
Thiopental 2 mg/kg via intravenous in 30 seconds and dexmedetomidine 1 mcg/kg via intravenous in 10 minutes then 0.5 mcg/kg/hr via intravenous,Propofol 1 mg/kg + lidocaine 0.2 mg/kg via intravenous in
Experimental Drug,Active Comparator Drug
Thiopental+Dexmedetomidine,Propofol
Sponsors
Ramathibodi Hospital
Ramathibodi Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 10 Years
Inclusion criteria
Inclusion criteria: 1.The patients were 1 to 10 years old. 2.The patients were underwent MRI. 3.The patients had ASA physical status 1-3. 4.The patients did not eat at least 6 hours and they did not drink at least 2 hours before sedation. 5.The patients' parents accepted to join this study.
Exclusion criteria
Exclusion criteria: 1.The patients had heart disease. 2.The patients had respiratory tract infection. 3.The patients had sepsis or shock. 4.The patients had asthma. 5.The patients had history of allergy to thiopental, dexmedetomidine,and propofol. 6.The patients used psychiatric drugs, sedative drugs, alpha-2 agonist drugs, beta blocker drugs, and digoxin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of MRI 0-60 min after sedation Score of the patient's movement during sedation,Onset of sedation time After injection Time to sleep | — |
Secondary
| Measure | Time frame |
|---|---|
| Presedation behavior Before sedation Score of presedation behavior,Ramsay sedation score 0-60 min after sedation Score of sedation,Blood pressure 0-60 min after sedation Systolic and diatolic blood pressure (mmHg),Heart rate 0-60 min after sedation Heart rate (beats per min),Respiratory rate 0-60 min after sedation Respiratory rate (times per min),End-tidal CO2 0-60 min after sedation Carbondioxide in expiration (mmHg),Oxygen saturation 0-60 min after sedation Pulse oximetry (%),Recovery time After discontinue medication Time to wake up (Ramsay score 2),Discharge time After discontinue medication Time to discharge from recovery room,Adverse events After injection until discharge from recovery room Record of adverse event | — |
Countries
Thailand
Contacts
Public ContactNarut Ruananukun
Ramathibodi Hospital
Outcome results
None listed