Graves’ hyperthyroidism Graves’ hyperthyroidism,
Conditions
Interventions
one group (92 cases) was assigned to discontinue (DISCONT-
ATD) ,the other (92 cases) was assigned to continue low-
dose ATD (CONT-
ATD).
Continue,Discontinue
Sponsors
None
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Graves' hyperthyroidism was based on clinical and biochemical features including presence of signs and symptoms of thyrotoxicosis, diffuse enlargement of thyroid gland, and elevated serum free thyroid hormones accompanied with suppressed serum thyroid-stimulating hormone (TSH) levels.
Exclusion criteria
Exclusion criteria: Patients who were suspected to have the causes of hyperthyroidism other than Graves’ disease (i.e., toxic multinodular goiter, toxic adenoma and thyroiditis), radioactive iodine uptake and/or technetium pertechnetate thyroid scan were performed as indicated to verify the diagnosis. Patients who had the causes of hyperthyroidism other than Graves’disease and had recurrent hyperthyroidism were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relapsed rate between 2 groups (continue vs. discontinue medication) 6,12,18,24 and 36 months after randomization T3 and TSH were measured by electrochemiluminescent immunoassay (CLIA) method using an automated mac | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Public ContactTada Kunavisarut
Mahidol University
Outcome results
None listed