a history of generalized moderate/severe chronic periodontitis Biomarkers, Periodontal disease(s)/periodontitis, Bone remodeling/regeneration, Cytokine(s), Orthodontic(s)
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1) a history of generalized moderate/severe chronic periodontitis, as defined by Armitage (1999) 2) presently in the periodontal maintenance phase 3) upper incisors exhibiting a horizontal bone loss pattern with PTM and no incisal stop.
Exclusion criteria
Exclusion criteria: Patients with allergies, systemic diseases including uncontrolled osteoporosis, or long-term use of cigarettes or medications (e.g. anti-inflammatories, immunosuppressants, bisphosphonates, steroids) were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alveolar bone changes initial (T0), ICS obtained(T1), 7th after ICS obtained (T3) mm changes from Cone beam computed tomography,RANKL/OPG initial (T0), ICS obtained(T1), 1mth after ICS obtained and 7th after ICS obtained (T3) ELISA kits | — |
Secondary
| Measure | Time frame |
|---|---|
| Tooth mobility initial (T0), ICS obtained(T1), 1mth after ICS obtained and 7th after ICS obtained (T3) Miller grade | — |
Countries
Thailand
Contacts
Faculty of Dentistry, Prince of Songkla University