helicobacter pylori Quadruple therapy eradication drug resistance helicobacter pylori Quadruple therapy eradication drug resistance
Conditions
Interventions
with high dose of drugs Metronidazole 500mg ,
Amoxicillin 1000 ,
Bismuth subcitrate240 ,
and omeprazole 20mg all three times a day for Two weeks,with omprazole 20mg twice a day,
bismuth 4 times a day,
tetracycline HCl 500 mg 4 times a day,
metronidazole 500 mg 3 times a day for 14 days. PPI and bismuth were taken before meal,
and antibiotics were used after meal.
Treatment,Treatment
amoxicillin group,tetracycline group
Sponsors
Shahid Sadoughi University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients were eligible if they were aged 18 years or older and had confirmed H pylori infection. H pylori infection was diagnosed by either a positive rapid urease test or positive identification of H pylori in a histological sample using haematoxylin and eosin and/or Giemsa stain
Exclusion criteria
Exclusion criteria: Patients were excluded if they had any of the followings: previous eradication therapy for H pylori; known allergies to any of the study medications; recent use of antibiotics, bismuth salts, probiotic preparations, proton pump inhibitors or non-steroidal antiinflammatory drugs in the preceding 1 month; pregnant or lactating women; previous gastric surgery; alcohol or drug abuse; or severe concurrent medical illnesses, such as liver failure, renal failure or terminal malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| side-effect 2 week after start questionnaire | — |
Secondary
| Measure | Time frame |
|---|---|
| Eradication of helicobacter pylori 8 weeks after complete treatment C13 urea breath test | — |
Countries
iran
Contacts
Public Contacthassan salmanroghani
Shahid Sadoughi University of Medical Sciences
Outcome results
None listed