Intradialytic left ventricular fucntion
Conditions
Interventions
Dialysate calcium during hemodialysis of 1.25 mmol/L,Dialysate calcium during hemodialysis of 1.75 mmol/L
Experimental Procedure/Surgery,Active Comparator Procedure/Surgery
Dialysate calcium concentration 1.25 mmol/L ,Dialysate calcium concentration 1.75 mmol/L
Sponsors
Renal Division, Department of Internal Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Age more than 18 years old - End-stage renal disease (defined by estimated glomerular filtration rate <15 ml/min/1.73 m2 which require long-term hemodialysis - Hemodialysis vintage of more than 3 months - Hemodialysis 3 sessions per week
Exclusion criteria
Exclusion criteria: - >2 episodes of intradialytic hypotension which required immediate treatment prior to randomization - Active cardiac disease (e.g., acute myocardial infarction, heart failure, arrhythmia) - Sepsis/septic shock - Require ultrafiltration more than 3.5 L/session - Active malignancy - Documented reduced left ventricular ejection fraction (LVEF 10.5 mg/dl) or hypocalcemia (serum calcium <7 mg/dl) prior to enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intradialytic left ventricular systolic function Post hemodialysis Ejection fraction | — |
Secondary
| Measure | Time frame |
|---|---|
| Intradialytic hypotension before hemodialysis, every 30 minutes during hemodialysis, and 5 minutes after hemodialysis Blood pressure,Fibroblast growth factor-23 month 6 Sandwich ELISA (Merk, USA) | — |
Countries
Thailand
Contacts
Public ContactKajohnsak Noppakun
Chiang Mai University
Outcome results
None listed