patient have knee pain with the diagnosis of osteoarthritis. The patient have been scheduled for unilateral total knee arthroplasty. Total knee arthroplasty,
Conditions
Interventions
Patient undergo unilateral TKA will be randomized to receive the Parecoxib for pain management in TKA. After 48 hours,
patient will receive Celebrex instead for pain management. ,Patient undergo unilateral TKA will be randomized to receive the Ketorolac for pain management in TKA. After 48 hours,
patient will receive Naproxen instead for pain management.
Active Comparator Drug,Active Comparator Drug
Parecoxib group,Ketorolac group
Sponsors
None
Eligibility
Sex/Gender
All
Age
20 Years to 90 Years
Inclusion criteria
Inclusion criteria: patient have knee pain with the diagnosis of osteoarthritis. And the patient have been scheduled for unilateral total knee arthroplasty.
Exclusion criteria
Exclusion criteria: 1. pregnant 2. had previous knee surgery 3. History of knee infection 4. allergy to medicine used in the trials 5. history of deep vein thrombosis 6. heart disease 7. cerebrovascular disease 8. peptic ulcer 9. kidney disease 10. liver disease 11. Hemoglobin less than 30 mg/dl
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score 6, 12,24, 48, 72, 96 hour postoperative Visual analoque scale,Degree of Knee flexion, Straight leg raising and extension lag 6, 12,24, 48, 72, 96 hour postoperative Goniometer,Morphine consumption 24, 48, 72, 96 hour postoperative amount of morphine use from PCA | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative blood loss preoperative and 24 hour postoperative Balance calculation method,Drainage blood loss 24, 48 hour postoperative Amount of blood discharge in drain,Renal function 6, 12,24, 48, 72, 96 hour postoperative Creatine clearance | — |
Contacts
Public ContactArtit Laoruengthana
Department of Orthopaedics, Faculty of Medicine, Naresuan university
Outcome results
None listed