Blood Loss Reduction: Effect of Tranexamic Acid Routes in Different Knee Prosthesis: A Randomized Controlled Trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20170618001

Enrollment

Unknown

Registered

2017-06-18

Start date

2015-01-30

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with primary osteoarthritis knee scheduled for unilateral primary total knee arthroplasty (TKA) Primary TKA&#44

Interventions

Closed&#45

box knee prosthesis without TXA (tranexamic acid) administration. A control group.,Closed&#45

box knee prosthesis with intravenous (IV) TXA administration.,Closed&#45

box knee prosthesis with intra&#45

articular (IA) TXA administration.,Open&#45

box knee prosthesis without TXA (tranexamic acid) administration. A control group.,Open&#45

articular (IA) TXA administration.

No Intervention No treatment,Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery,No Intervention No treatment,Active Comparator Procedure/Surgery,Active Comparator Procedure/Surger

box none&#45

TXA,Closed&#45

box IV&#45

box IA&#45

TXA,Open&#45

Eligibility

Sex/Gender

All

Age

20 Years to No maximum

Inclusion criteria

Inclusion criteria: All patients with the diagnosis of primary osteoarthritis knee scheduled for unilateral primary total knee arthroplasty (TKA) in Naresuan university hospital were enrolled.

Exclusion criteria

Exclusion criteria: Patients with preop hemoglobin level less than 10g/dL, previous history of thromboembolic event, renal insufficiency, cardiovascular disease or cerebrovascular accident were excluded.

Design outcomes

Primary

Measure	Time frame
Blood loss 6,12,24,48,72,96 hr postop Perioperative blood loss, drainage blood loss, postop hemoglobin level	—

Secondary

Measure	Time frame
pain score 6,12,24,48,72,96 hr postop visual analogue scale,knee flexion, Straight leg raising, extension lag 6,12,24,48,72,96 hr postop goniometer	—

Countries

Thailand

Contacts

Public ContactArtit Laoruengthana

Orthopaedic department, faculty of medicine, Naresuan university

artitlao@gmail.com+66851102799

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026