balanced salt solution versus normal saline in resuscitation of pediatric sepsis: A double-blinded randomized control trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20170605001

Enrollment

Registered

2017-06-05

Start date

2017-06-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

metabolic acidosis hyperchloremic metabolic acidosis lactate clearance renal injury coagulopathy length of stay balanced salt solution pediatric sepsis septic shock shock fluid normal saline renal injury fluid&#45

Interventions

Placebo Comparator Drug,Active Comparator Drug,Active Comparator Drug

normal saline,ringer&#39

s lactate solution,sterofundin

3 doses until hemodynamically stable

3 doses until hemodynamically stable,bolus of sterofundion 20 mL/kg/dose intravenously for 2 &#45

bolus of NSS 20 mL/kg/dose intravenously for 2 &#45

3 doses until hemodynamically stable,bolus of RLS 20 mL/kg/dose intravenously for 2 &#45

Eligibility

Sex/Gender

All

Age

1 Months to 18 Years

Inclusion criteria

Inclusion criteria: pediatric patients diagnosed as septic shock, requiring fluid bolus therapy

Exclusion criteria

Exclusion criteria: pre-existing renal failure uncontrolled liver failure

Design outcomes

Primary

Measure	Time frame
acid-base status 2 hr, 6 hr, 24 hr lactate clearance, blood pH, base excess	—

Secondary

Measure	Time frame
fluid-related complications 2 hr, 6 hr, 24 hr, 48 hr, 72 hr, 96 hr renal injury (urinary neutrophil gelatinase-associated lipocalin, creatinine, renal replacement ther	—

Countries

Thailand

Contacts

Public ContactSirawut Trepatchayakorn

Department of Pediatrics, Faculty of Medicine, Chulalongkorn University

sirawut.t@chula.ac.th0809995805

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

balanced salt solution versus normal saline in resuscitation of pediatric sepsis: A double&#45;blinded randomized control trial