childhood acanthosis nigricans Acanthosis nigricans childhood Topical retinoid
Conditions
Interventions
Adapalene is a third-
generation topical retinoid primarily used in the treatment of mild-
moderate acne,
and is also used off-
label to treat keratosis pilaris as well as other skin conditions. Adapalene was approved in 1996 by the U.S. Food and Drug Administration (FDA) for use in the treatment of acne,Tretinoin is medicatio
Active Comparator Drug,Active Comparator Drug
adapalene,tretinoin
Sponsors
Faculty of Medicine, Srinakhariwirot University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: The participants aged 12 -18 years with a diagnosis of acanthosis nigricans
Exclusion criteria
Exclusion criteria: - Vulnerable skin diseases - Infectious skin diseases - Other recent diseases involving the neck - Other serious medical disorders e.g. DM, liver disease - Any patients having received other therapies for up to 4 weeks prior to enrollment. - Photosensitive skin - Immunocompromised host - Pregnancy and lactation - Receiving oral retinoids - Neck tattoo
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| erythema index and melanin index at the baseline, at week 2, 4 and 8. Mexameter | — |
Secondary
| Measure | Time frame |
|---|---|
| The efficacy of the treatment at the baseline, at week 2, 4 and 8. investigator’s global evaluation (IGE) scale and the parent’s global evaluation (PGE) | — |
Countries
Thailand
Contacts
Public ContactArucha Treesirichod
Unaffiliated
Outcome results
None listed