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Efficacy of once daily versus divided daily administration of low daily dosage (15 mg/day) of methimazole in the induction of euthyroidism in Graves' hyperthyroidism: A randomized controlled study

Efficacy of once daily versus divided daily administration of low daily dosage (15 mg/day) of methimazole in the induction of euthyroidism in Graves’ hyperthyroidism: A randomized controlled study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20170529001
Enrollment
Unknown
Registered
2017-05-29
Start date
2010-01-06
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Graves’ hyperthyroidism Graves’ hyperthyroidism&#44

Interventions

one group was treated with 15 mg/day of MMI which was administered once a day (15 mg/day&#45
OD&#45
MMI) ,the other group was treated with 15 mg/day of MMI which was dividedly administered in 5 mg three times a day (15 mg/day&#45
DD&#45
MMI)
Active Comparator Drug,Active Comparator Drug
Once a day (15 mg/day&#45
MMI),three times a day (15 mg/day&#45

Sponsors

None
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Graves' hyperthyroidism was based on clinical and biochemical features including presence of signs and symptoms of thyrotoxicosis, diffuse enlargement of thyroid gland, and elevated serum free thyroid hormones accompanied with suppressed serum thyroid-stimulating hormone (TSH) levels.

Exclusion criteria

Exclusion criteria: Other causes of thyrotoxicosis

Design outcomes

Primary

MeasureTime frame
To compare the efficacy in the reduction of serum thyroid hormone levels before and at 2, 4, 8 and 12 weeks of the study comparing results of FT3, FT4—

Secondary

MeasureTime frame
N/A N/A N/A—

Countries

Thailand

Contacts

Public ContactTada Kunavisarut

Mahidol University

kunavisarut@gmail.com0843878300

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026